Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells
نویسندگان
چکیده
Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands: EG, CL, CT, KS, JAR, GJP; Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa; Italy: EG, SN, SR, RD; Medical Oncology Branch, National Cancer Institute, Bethesda, MD, US: GG Molecular Pharmacology Fast Forward. Published on January 10, 2008 as doi:10.1124/mol.107.042382
منابع مشابه
Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells.
Because the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib and the multitargeted antifolate pemetrexed are registered in the treatment of second-line non-small-cell lung cancer (NSCLC), empirical combinations of these drugs are being tested. This study investigated molecular mechanisms underlying their combination in six NSCLC cell lines. Cells were characterized by...
متن کاملMOL #42382 1 Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells
Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands: EG, CL, CT, KS, JAR, GJP; Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa; Italy: EG, SN, SR, RD; Medical Oncology Branch, National Cancer Institute, Bethesda, MD, US: GG Molecular Pharmacology Fast Forward. Published on January 10, 2008 as doi:10.1124/mol.107...
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